Effect Of Ocimum Sanctum Leaf Extract On Swimming Stress Induced Ulcers In Rats

Ocimum sanctum is a medicinal plant which has been used studied for various properties and used in various conditions.In the present study, ocimum sanctum was investigated for its effects against swimming stress induced ulcers in albino rats. The effects were compared with ranitidine. The leaf extract of ocimum sanctum showed significant antiulcer activity in the dose of 100 mg/kg and 200 mg/kg. The results were comparable to ranitidine though ranitidine was found to be more potent. Ocimum sanctum may be operating by antagonism of H2 receptors, by antisecretory mechanism or by antioxidant property as an antiulcer agent against stress induced gastric ulcers. Since this drug has been documented to have antiulcerogenic property earlier and has shown significant activity in the present study, more studies are required to explore its complete therapeutic usefulness.